Aim of this research was to synthesize, characterize and antimicrobial evaluation of dipeptides. Solid phase peptide synthesis (SPPS) by fluorenyl methyl oxycarbonyl (Fmoc) chemistry protocol method was used. The compounds DP1 and DP2 were found to be extremely powerful inhibition against Bacillus subtillis at 6.25 µg/ml and Escherichia coli and Pseudomonas vulgaris at 12.5 µg/ml than standard (25 µg/ml). The percentage of reduction in the relative light unit (RLU) of the compound DP2 was 53.53% and 60.99% at 100 µg/ml against Mycobacterium tuberculosis H37Rv and clinical isolate of Mycobacterium tuberculosis (streptomycin, isoniazid, rifampicin and ethamputol resistant) as compared with control. Dipeptides were synthesized, characterized and exhibited promising antibacterial, antifungal and antimycobacterial activity.
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